Amphotericin b
Abelcet, Ambisome, Amphotericin B (amphotericin b) is a small molecule pharmaceutical. Amphotericin b was first approved as Fungizone on 1982-01-01. It is used to treat aids-related opportunistic infections, aspergillosis, blastomycosis, chronic mucocutaneous candidiasis, and coccidioidomycosis amongst others in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Abelcet, Ambisome, Amphotericin b (discontinued: Amphotec, Amphotericin b, Fungizone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amphotericin b
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AMBISOME | Astellas Pharma | N-050740 RX | 1997-08-11 | 1 products, RLD, RS |
| ABELCET | Leadiant Biosciences | N-050724 RX | 1995-11-20 | 1 products, RLD, RS |
Show 4 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| abelcet | New Drug Application | 2023-11-21 |
| ambisome | New Drug Application | 2020-08-14 |
| amphotec | 2006-02-27 | |
| amphotericin b | ANDA | 2022-11-17 |
Indications
FDA
EMA
Show 8 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB04: Amphotericin b
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA07: Amphotericin b
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AA: Antibiotics, gynecological
— G01AA03: Amphotericin b
J: Antiinfectives for systemic use
— J02: Antimycotics for systemic use
— J02A: Antimycotics for systemic use
— J02AA: Antibiotics for systemic use
— J02AA01: Amphotericin b
Clinical
Clinical Trials
183 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | 2 | 6 | 9 | 7 | 8 | 32 |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | 5 | 15 | 10 | 4 | 2 | 31 |
| Meningitis | D008581 | HP_0001287 | G03 | 4 | 10 | 6 | 2 | 11 | 29 |
| Cryptococcal meningitis | D016919 | EFO_0007228 | B45.1 | 4 | 10 | 6 | 2 | 11 | 29 |
| Infections | D007239 | EFO_0000544 | — | 2 | 4 | 10 | 3 | 7 | 25 |
| Aspergillosis | D001228 | EFO_0007157 | B44 | 1 | 10 | 11 | 2 | 2 | 23 |
| Visceral leishmaniasis | D007898 | — | B55.0 | 2 | 9 | 7 | 4 | 1 | 22 |
| Invasive fungal infections | D000072742 | — | — | 2 | 2 | 3 | 3 | 8 | 18 |
| Candidiasis | D002177 | — | B37 | — | 6 | 6 | 2 | 3 | 17 |
| Communicable diseases | D003141 | — | — | 1 | 3 | 4 | 1 | 4 | 12 |
Show 25 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 4 | 5 | — | 10 | 21 |
| Neoplasms | D009369 | — | C80 | — | 1 | 3 | — | — | 4 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | — | — | 1 | — | 3 | 4 |
| Lung transplantation | D016040 | — | — | — | 1 | 3 | — | — | 4 |
| Fever | D005334 | HP_0001945 | R50.9 | — | 1 | 2 | — | — | 3 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | 1 | — | 2 | — | — | 3 |
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | — | 2 | 1 | — | — | 3 |
| Keratitis | D007634 | HP_0000491 | H16 | — | — | 1 | — | 2 | 3 |
| Ulcer | D014456 | MPATH_579 | — | 1 | 1 | 1 | — | — | 3 |
| Histoplasmosis | D006660 | EFO_0007310 | B39 | — | 1 | 2 | — | — | 3 |
Show 24 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mucormycosis | D009091 | EFO_0007380 | B46.5 | 1 | 5 | — | — | 1 | 6 |
| Zygomycosis | D020096 | — | B46 | 1 | 5 | — | — | 1 | 6 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 4 | — | — | — | 4 |
| Myeloid leukemia | D007951 | — | C92 | — | 4 | — | — | — | 4 |
| Cutaneous leishmaniasis | D016773 | — | B55.1 | 2 | 3 | — | — | 1 | 4 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | 3 | — | — | — | 3 |
| Vulvovaginitis | D014848 | EFO_1001240 | N76.0 | — | 2 | — | — | — | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 1 | — | — | — | 2 |
| Rhinosinusitis | D000096825 | — | — | — | 1 | — | — | — | 1 |
| Varicose ulcer | D014647 | — | — | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | — | — | 1 |
| Wound infection | D014946 | — | — | 1 | — | — | — | — | 1 |
| Foot ulcer | D016523 | — | — | 1 | — | — | — | — | 1 |
| Fibrosis | D005355 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 2 | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | — | — | 1 | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | — | 1 | 1 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 1 | 1 |
| Liver failure | D017093 | HP_0001399 | K72.9 | — | — | — | — | 1 | 1 |
| Hepatic insufficiency | D048550 | — | — | — | — | — | — | 1 | 1 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Amphotericin b |
| INN | amphotericin b |
| Description | Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. For certain infections it is given with flucytosine. It is typically given intravenously (injection into a vein).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@@H](C(=O)O)[C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2 |
Identifiers
| PDB | — |
| CAS-ID | 1397-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL267345 |
| ChEBI ID | 2682 |
| PubChem CID | 14956 |
| DrugBank | DB00681 |
| UNII ID | 7XU7A7DROE (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Ambisome – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
Amphotericin b
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 90,285 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
13,116 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use