Amphotericin b
Abelcet, Ambisome, Amphotericin B (amphotericin b) is a small molecule pharmaceutical. Amphotericin b was first approved as Fungizone on 1982-01-01. It is used to treat aids-related opportunistic infections, aspergillosis, blastomycosis, chronic mucocutaneous candidiasis, and coccidioidomycosis amongst others in the USA.
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Trade Name
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Abelcet, Ambisome, Amphotericin b (discontinued: Amphotec, Amphotericin b, Fungizone)
Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Amphotericin b
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AMBISOME | Astellas Pharma | N-050740 RX | 1997-08-11 | 1 products, RLD, RS |
| ABELCET | Leadiant Biosciences | N-050724 RX | 1995-11-20 | 1 products, RLD, RS |
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Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| abelcet | New Drug Application | 2023-11-21 |
| ambisome | New Drug Application | 2024-11-04 |
| amphotec | 2006-02-27 | |
| amphotericin b | ANDA | 2024-11-28 |
Indications
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ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB04: Amphotericin b
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA07: Amphotericin b
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AA: Antibiotics, gynecological
— G01AA03: Amphotericin b
J: Antiinfectives for systemic use
— J02: Antimycotics for systemic use
— J02A: Antimycotics for systemic use
— J02AA: Antibiotics for systemic use
— J02AA01: Amphotericin b
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Drug
General
| Drug common name | Amphotericin b |
| INN | amphotericin b |
| Description | Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. For certain infections it is given with flucytosine. It is typically given intravenously (injection into a vein).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@@H](C(=O)O)[C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2 |
Identifiers
| PDB | — |
| CAS-ID | 1397-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL267345 |
| ChEBI ID | 2682 |
| PubChem CID | 14956 |
| DrugBank | DB00681 |
| UNII ID | 7XU7A7DROE (ChemIDplus, GSRS) |
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Ambisome – Gilead Sciences
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Amphotericin b
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